Expresión génica y receptores hormonales en cáncer mamario: El camino hacia la búsqueda de terapias preventivas

Abstract

Abstract Breast cancer is the leading cause of death from neoplastic disease in women, in Mexico and the world. The study of gene expression is a key part for understanding the origin of the cancer, as well as analysis of origin promoter mutations, which are involved in cancer development, recently published studies demonstrate that mutations in the somatic cells, alterations in maternal hormonal environment, and inherited variants carrying mutations in their genomes somatic mutation and drivers mutations related to the expression of estrogen receptors, progesterone receptor, HER-2 and leptin, are issues related to the elucidation of molecular subtypes of breast cancer, which are analyzed in this review. The management of molecular subtypes in clinical staging or grant will allow a degree of specific cell differentiation most likely help the clinician to be more preventive and decision tools for specific treatments and therefore a greater survival period patient. The analysis of molecular subtypes and hormone receptors, will reveal more about the origin of breast cancer, and identify ways to develop effective preventive therapies.