POLYMORPHISMS OF GSTM1, GSTT1 AND GSTP1 AND THEIR POSSIBLE ASSOCIATION WITH THE DEVELOPMENT OF DENTAL CARIES. PILOT STUDY

Abstract

Objective: The purpose of this investigation was to study the relationship between the polymorphisms of GSTM1, GSTT1 and GSTP1 with the susceptibility to dental caries in Mexican. Methods: In a group of 64 individuals, the DMFT index and GST polymorphisms were determined and related. Results: The frequencies for GSTM1 were 48.4% with the wild allele and 51.6% null, with a mean DMFT of 6.1 and 5.5 respectively. For GSTT1 were 73.4% with the wild allele and 26.6% null, with a mean DMFT of 6.6 and 5.8, respectively. In GSTP1 exon 5, 23.4% with the wild allele, 53.2% (a/b) and 23.4% (b/b), the mean DMFT was 4.3, 6.6 and 5.9 respectively. 100% had the GSTP1 exon 6 wild genotype, with a mean DMFT of 6.4%. In the combined genotypes, the lower DMFT corresponds to the GSTM1 wild type genotype, GSTT1 wild type, GSTP1 exon 5 wild type, GSTP1c wild type and the highest DMFT value to GSTM1 null genotype; GSTT1 null; GSTP1 exon 5 a/b; GSTP1 exon 5 a/a.