BDNF expression in blood. Study in iron deficient females

Abstract

Iron deficiency is a public health problem that greatly impacts women and children, especially at the neurological level, being BDNF a relevant factor involved in such pathogeny. Objectives: To determine in females suffering from chronic iron deficiency, from the perinatal stage to adulthood, the levels of peripheral BDNF in blood. In addition, the effect of iron supplementation after weaning. Methodology: female Wistar rats with chronic iron deficiency and rats supplemented from weaning to adulthood (70 postnatal days) were euthanized to analyze BDNF levels in blood samples. Contribution: we demonstrate that in the presence of chronic iron deficiency, BDNF levels decrease peripherally and supplementation normalizes them. In addition, hemoglobin-bound iron (Fe-Hb) levels correlate positively with BDNF levels in blood. This could indirectly indicate a possible restoration or contribution to the improvement of the patient's cognitive or behavioral processes