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dc.contributor.author Olmos Ramírez, Rocío Lizbeth
dc.contributor.author Peña Castillo, Miguel Ángel
dc.contributor.author Mendieta Zerón, Hugo
dc.contributor.author Reyes-Lagos, José Javier
dc.date.accessioned 2024-10-29T21:20:19Z
dc.date.available 2024-10-29T21:20:19Z
dc.date.issued 2023-01-12
dc.identifier.issn 1664-2392
dc.identifier.uri http://hdl.handle.net/20.500.11799/141490
dc.description.abstract Background: The autonomic nervous system of preterm fetuses has a different level of maturity than term fetuses. Thus, their autonomic response to transient hypoxemia caused by uterine contractions in labor may differ. This study aims to compare the behavior of the fetal autonomic response to uterine contractions between preterm and term active labor using a novel time-frequency analysis of fetal heart rate variability (FHRV). Methods: We performed a case-control study using fetal R-R and uterine activity time series obtained by abdominal electrical recordings from 18 women in active preterm labor (32-36 weeks of gestation) and 19 in active term labor (39-40 weeks of gestation). We analyzed 20 minutes of the fetal R-R time series by applying a Continuous Wavelet Transform (CWT) to obtain frequency (HF, 0.2-1 Hz; LF, 0.05-0.2 Hz) and time-frequency (Flux0, Flux90, and Flux45) domain features. Time domain FHRV features (SDNN, RMSSD, meanNN) were also calculated. In addition, ultra-short FHRV analysis was performed by segmenting the fetal R-R time series according to episodes of the uterine contraction and quiescent periods. Results: No significant differences between preterm and term labor were found for FHRV features when calculated over 20 minutes. However, we found significant differences when segmenting between uterine contraction and quiescent periods. In the preterm group, the LF, Flux0, and Flux45 were higher during the average contraction episode compared with the average quiescent period (p<0.01), while in term fetuses, vagally mediated FHRV features (HF and RMSSD) were higher during the average contraction episode (p<0.05). The meanNN was lower during the strongest contraction in preterm fetuses compared to their consecutive quiescent period (p=0.008). Conclusion: The average autonomic response to contractions in preterm fetuses shows sympathetic predominance, while term fetuses respond through parasympathetic activity. Comparison between groups during the strongest contraction showed a diminished fetal autonomic response in the preterm group. Thus, separating contraction and quiescent periods during labor allows for identifying differences in the autonomic nervous system cardiac regulation between preterm and term fetuses. es
dc.description.sponsorship JR-L thanks to the Secretarı́a de Investigació n y Estudios Avanzados (SIEA) de la Universidad Autó noma del Estado de Mé xico. RO-R thanks the Mexican National Council on Science and Technology (CONACyT) for providing a scholarship for studying a master’s degree at Universidad Autó noma Metropolitana (CVU# 1082248). es
dc.language.iso eng es
dc.publisher Frontiers in Endocrinology es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by/4.0 es
dc.subject Autonomic function es
dc.subject Continuous wavelet transform es
dc.subject Fetal heart rate variability es
dc.subject Preterm labor es
dc.subject Uterine contractions. es
dc.subject.classification MEDICINA Y CIENCIAS DE LA SALUD es
dc.title Uterine activity modifies the response of the fetal autonomic nervous system at preterm active labor es
dc.type Artículo es
dc.provenance Científica es
dc.road Dorada es
dc.ambito Nacional es
dc.relation.vol 2023
dc.validacion.itt No es


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  • Título
  • Uterine activity modifies the response of the fetal autonomic nervous system at preterm active labor
  • Autor
  • Olmos Ramírez, Rocío Lizbeth
  • Peña Castillo, Miguel Ángel
  • Mendieta Zerón, Hugo
  • Reyes-Lagos, José Javier
  • Fecha de publicación
  • 2023-01-12
  • Editor
  • Frontiers in Endocrinology
  • Tipo de documento
  • Artículo
  • Palabras clave
  • Autonomic function
  • Continuous wavelet transform
  • Fetal heart rate variability
  • Preterm labor
  • Uterine contractions.
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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