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dc.contributor.author	LF Vega
dc.contributor.author	R Montes de Oca
dc.contributor.author	B Valladares
dc.contributor.author	S Martínez-Castañeda
dc.contributor.author	U Alonso
dc.contributor.author	R Enríquez
dc.contributor.author	C Ortega
dc.creator	LF Vega
dc.creator	R Montes de Oca
dc.creator	B Valladares
dc.creator	S Martínez-Castañeda
dc.creator	U Alonso
dc.creator	R Enríquez
dc.creator	C Ortega
dc.date	2011
dc.date.accessioned	2016-03-16T17:19:32Z
dc.date.available	2016-03-16T17:19:32Z
dc.identifier	http://www.redalyc.org/articulo.oa?id=173019392004
dc.identifier.uri	http://hdl.handle.net/20.500.11799/40065
dc.description	The aim of this study was to assess the relationship between the clinical-pathologic process in rainbow trout fry (Oncorhynchus mykiss) infected with infectious pancreatic necrosis virus (IPNV) and the immunoglobulin M (IgM) levels in blood serum. Parameters were evaluated up to 45 days post infection (dpi) in fish intraperitoneally inoculated (IP) with 1X10(4) TCDI of IPNV, with minimal essential medium (MEM) and in the control group. Infected fish showed classical signs of infectious pancreatic necrosis (IPN) disease since day 19 pi, reaching 70% of accumulated mortality, and the survivor fish showed emaciation and IgM blood serum levels which progressively increased up to its maximum peak at day 31 pi; the most significant histopathological changes were the increase in melanomacrophage centers in the kidney, pancreatic necrosis and catarrhal enteritis. Viral isolation was possible only in the infected fish starting at day 3 pi up to day 45 (P > 0.5). The results suggest that even though the fish infected with IPNV can develop a humoral immune response characterized by the increase in IgM levels, this is insufficient to develop protection because while IgM levels are increasing, so does the viral title accompanied by clinical signs and histopathological injuries that are typical of the disease.
dc.format	application/pdf
dc.language	spa
dc.publisher	Universidad Austral de Chile
dc.relation	http://www.redalyc.org/revista.oa?id=1730
dc.rights	openAccess
dc.rights	Archivos de Medicina Veterinaria
dc.source	Archivos de Medicina Veterinaria (Chile) Num.1 Vol.43
dc.subject	Veterinaria
dc.subject	IPNV
dc.subject	IgM
dc.subject	virus
dc.subject	immune response
dc.title	Evaluación de la respuesta clínico-patológica e inmune humoral en crías de trucha arco iris (Oncorhynchus mykiss) infectadas experimentalmente con el virus de la Necrosis Pancreática Infecciosa (IPNV)
dc.type	Artículo
dc.provenance	Científica
dc.road	Dorada

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