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dc.contributor.author ISLAS FLORES, HARIZ
dc.contributor.author Gómez Olivan, Leobardo Manuel
dc.contributor.author GALAR MARTINEZ, MARCELA
dc.contributor.author SANCHEZ OCAMPO, ESMERALDA MICHELLE
dc.contributor.author SAN JUAN REYES, NELY
dc.contributor.author ORTIZ REYNOSO, MARIANA
dc.contributor.author DUBLAN GARCIA, OCTAVIO
dc.creator ISLAS FLORES, HARIZ; 265074
dc.creator Gómez Olivan, Leobardo Manuel; 201091
dc.creator GALAR MARTINEZ, MARCELA; 121303
dc.creator SANCHEZ OCAMPO, ESMERALDA MICHELLE; 891446
dc.creator SAN JUAN REYES, NELY; 413086
dc.creator ORTIZ REYNOSO, MARIANA; 40498
dc.creator DUBLAN GARCIA, OCTAVIO; 36251
dc.date.accessioned 2017-11-07T01:57:45Z
dc.date.available 2017-11-07T01:57:45Z
dc.date.issued 2017-01-19
dc.identifier.issn 1522-7278
dc.identifier.uri http://hdl.handle.net/20.500.11799/67579
dc.description.abstract Thirty million people worldwide consume each day nonsteroidal anti-inflammatory drugs (NSAIDs), a heterogeneous group of pharmaceuticals used for its analgesic, antipyretic, and anti- inflammatory properties. Recent studies report high NSAID concentrations in wastewater treat- ment plant effluents, in surface, ground, and drinking water, and in sediments. NSAIDs are also known to induce toxicity on aquatic organisms. However, toxicity in natural ecosystems is not usu- ally the result of exposure to a single substance but to a mixture of toxic agents, yet only a few studies have evaluated the toxicity of mixtures. The aim of this study was to evaluate the toxicity induced by diclofenac (DCF), ibuprofen (IBP), and their mixture on a species of commercial inter- est, the common carp Cyprinus carpio. The median lethal concentration of IBP and DCF was determined, and oxidative stress was evaluated using the following biomarkers: lipid peroxidation and activity of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxi- dase. Cyto-genotoxicity was evaluated by micronucleus test, comet assay, and the specific activity of caspase-3. Results show that DCF, IBP, and a mixture of these pharmaceuticals induced free radical production, oxidative stress and cyto-genotoxicity in tissues of C. carpio. However, a greater effect was elicited by the mixture than by either pharmaceutical alone in some biomarkers evaluated, particularly in gill. es
dc.description.sponsorship Secretaria de Investigacion y Estudios Avanzados de la UAEM (Project 3722/ 2014CID). es
dc.language.iso eng es
dc.publisher Wiley
dc.relation.ispartofseries 32(5);1637-1650
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0
dc.subject caspase-3 es
dc.subject comet assay es
dc.subject Cyprinus carpio es
dc.subject micronucle es
dc.subject nonsteroidal anti-inflammatory drugs es
dc.subject oxidative stress es
dc.subject.classification BIOLOGÍA Y QUÍMICA
dc.title Cyto-genotoxicity and oxidative stress in common carp (Cyprinus carpio) exposed to a mixture of ibuprofen and diclofenac es
dc.type Artículo es
dc.provenance Científica es
dc.road Dorada es
dc.organismo Química es
dc.ambito Internacional es
dc.cve.CenCos 20401 es
dc.cve.progEstudios 747 es
dc.audience students es
dc.audience researchers es
dc.type.conacyt article
dc.identificator 2


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  • Título
  • Cyto-genotoxicity and oxidative stress in common carp (Cyprinus carpio) exposed to a mixture of ibuprofen and diclofenac
  • Autor
  • ISLAS FLORES, HARIZ
  • Gómez Olivan, Leobardo Manuel
  • GALAR MARTINEZ, MARCELA
  • SANCHEZ OCAMPO, ESMERALDA MICHELLE
  • SAN JUAN REYES, NELY
  • ORTIZ REYNOSO, MARIANA
  • DUBLAN GARCIA, OCTAVIO
  • Fecha de publicación
  • 2017-01-19
  • Editor
  • Wiley
  • Tipo de documento
  • Artículo
  • Palabras clave
  • caspase-3
  • comet assay
  • Cyprinus carpio
  • micronucle
  • nonsteroidal anti-inflammatory drugs
  • oxidative stress
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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