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dc.contributor.author | ISLAS FLORES, HARIZ | |
dc.contributor.author | Gómez Olivan, Leobardo Manuel | |
dc.contributor.author | GALAR MARTINEZ, MARCELA | |
dc.contributor.author | SANCHEZ OCAMPO, ESMERALDA MICHELLE | |
dc.contributor.author | SAN JUAN REYES, NELY | |
dc.contributor.author | ORTIZ REYNOSO, MARIANA | |
dc.contributor.author | DUBLAN GARCIA, OCTAVIO | |
dc.creator | ISLAS FLORES, HARIZ; 265074 | |
dc.creator | Gómez Olivan, Leobardo Manuel; 201091 | |
dc.creator | GALAR MARTINEZ, MARCELA; 121303 | |
dc.creator | SANCHEZ OCAMPO, ESMERALDA MICHELLE; 891446 | |
dc.creator | SAN JUAN REYES, NELY; 413086 | |
dc.creator | ORTIZ REYNOSO, MARIANA; 40498 | |
dc.creator | DUBLAN GARCIA, OCTAVIO; 36251 | |
dc.date.accessioned | 2017-11-07T01:57:45Z | |
dc.date.available | 2017-11-07T01:57:45Z | |
dc.date.issued | 2017-01-19 | |
dc.identifier.issn | 1522-7278 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11799/67579 | |
dc.description.abstract | Thirty million people worldwide consume each day nonsteroidal anti-inflammatory drugs (NSAIDs), a heterogeneous group of pharmaceuticals used for its analgesic, antipyretic, and anti- inflammatory properties. Recent studies report high NSAID concentrations in wastewater treat- ment plant effluents, in surface, ground, and drinking water, and in sediments. NSAIDs are also known to induce toxicity on aquatic organisms. However, toxicity in natural ecosystems is not usu- ally the result of exposure to a single substance but to a mixture of toxic agents, yet only a few studies have evaluated the toxicity of mixtures. The aim of this study was to evaluate the toxicity induced by diclofenac (DCF), ibuprofen (IBP), and their mixture on a species of commercial inter- est, the common carp Cyprinus carpio. The median lethal concentration of IBP and DCF was determined, and oxidative stress was evaluated using the following biomarkers: lipid peroxidation and activity of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxi- dase. Cyto-genotoxicity was evaluated by micronucleus test, comet assay, and the specific activity of caspase-3. Results show that DCF, IBP, and a mixture of these pharmaceuticals induced free radical production, oxidative stress and cyto-genotoxicity in tissues of C. carpio. However, a greater effect was elicited by the mixture than by either pharmaceutical alone in some biomarkers evaluated, particularly in gill. | es |
dc.description.sponsorship | Secretaria de Investigacion y Estudios Avanzados de la UAEM (Project 3722/ 2014CID). | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | |
dc.relation.ispartofseries | 32(5);1637-1650 | |
dc.rights | openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | caspase-3 | es |
dc.subject | comet assay | es |
dc.subject | Cyprinus carpio | es |
dc.subject | micronucle | es |
dc.subject | nonsteroidal anti-inflammatory drugs | es |
dc.subject | oxidative stress | es |
dc.subject.classification | BIOLOGÍA Y QUÍMICA | |
dc.title | Cyto-genotoxicity and oxidative stress in common carp (Cyprinus carpio) exposed to a mixture of ibuprofen and diclofenac | es |
dc.type | Artículo | es |
dc.provenance | Científica | es |
dc.road | Dorada | es |
dc.organismo | Química | es |
dc.ambito | Internacional | es |
dc.cve.CenCos | 20401 | es |
dc.cve.progEstudios | 747 | es |
dc.audience | students | es |
dc.audience | researchers | es |
dc.type.conacyt | article | |
dc.identificator | 2 |