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| dc.contributor.author | Medina-Mercado, Ignacio
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| dc.contributor.author | Zaragoza-Galicia, Ivann
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| dc.contributor.author | Olivo, Horacio F.
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| dc.contributor.author | Romero-Ortega, Moises
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| dc.date.accessioned | 2018-11-15T01:52:07Z | |
| dc.date.available | 2018-11-15T01:52:07Z | |
| dc.date.issued | 2018-07-16 | |
| dc.identifier.issn | 0039-7881 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11799/95180 | |
| dc.description | Se reporta una metodología para la preparación de trifluorometilpirimidinas | es |
| dc.description.abstract | A convenient two-step synthesis of 2-trichloromethyl-4-chloropyrimidines starting from 2-trichloromethyl-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared in one pot synthesis by a sequential acylation/intramolecular cyclization reaction between 2-trichloromethyl-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 2-trichloromethyl-4-chloropyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions. | es |
| dc.language.iso | eng | es |
| dc.publisher | Synthesis | es |
| dc.rights | embargoedAccess | es |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | es |
| dc.rights | embargoedAccess | es |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | es |
| dc.subject | Cycloaddition reaction | es |
| dc.subject | tetrachloropyrimidines | es |
| dc.subject | 1,3-diazadienes | es |
| dc.subject | intramolecular cyclization | es |
| dc.subject | nucleophilic substitution | es |
| dc.title | 2-Trifluoromethyl-1,3-diazabutadienes as useful intermediates for the construction of 2-trifluoromethylpyrimidine derivatives | es |
| dc.type | Artículo | es |
| dc.provenance | Científica | es |
| dc.road | Dorada | es |
| dc.organismo | Química | es |
| dc.ambito | Internacional | es |
| dc.cve.progEstudios | 57 | es |
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