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dc.contributor.author	PLATA VARGAS, EDUARDO
dc.contributor.author	De la Cruz Hernández, Cinthia Yareli
dc.contributor.author	DORAZCO GONZALEZ, ALEJANDRO
dc.contributor.author	FUENTES NORIEGA, INES
dc.contributor.author	MORALES MORALES, DAVID
dc.contributor.author	GERMAN ACACIO, JUAN MANUEL
dc.creator	PLATA VARGAS, EDUARDO; 811740
dc.creator	De la Cruz Hernández, Cinthia Yareli;#0000-0002-3169-8144
dc.creator	DORAZCO GONZALEZ, ALEJANDRO; 205445
dc.creator	FUENTES NORIEGA, INES; 253114
dc.creator	MORALES MORALES, DAVID; 19259
dc.creator	GERMAN ACACIO, JUAN MANUEL; 102452
dc.date.accessioned	2019-01-17T23:42:29Z
dc.date.available	2019-01-17T23:42:29Z
dc.date.issued	2017
dc.identifier	http://www.redalyc.org/articulo.oa?id=47553303004
dc.identifier.uri	http://hdl.handle.net/20.500.11799/97057
dc.description	The reaction by melt mixing at 220 °C of the antihypergly-cemic drug metformin hydrochloride1with dehydrated sodium suc-cinate yields efficiently the organic salt [MET]2[SUC]2(H-MET+=metforminium and SUC2-= succinate). Solid state CPMAS NMR13Cspectroscopy experiments, powder X-ray diffraction and FT-IR re-sults support the formation of the pharmaceutical salt2in goodyields. Besides, thecharged-assisted hydrogen bonding interactionsof type N-H...-O(carboxylate) were thoroughly analyzed by singlecrystal X-Ray diffraction techniques. Thus, the pharmaceutical salt2possesses considerable thermal differences when compared to thepure starting reagents. In addition, intrinsic dissolution rate expe-riments in buffered aqueous solutions at pH= 6.8 showed a sus-tained-release behavior of the drug in2with a constant value ofKint= 0.885 mg/min * cm2.
dc.format	application/pdf
dc.language.iso	eng	es
dc.publisher	Sociedad Química de México
dc.relation	http://www.redalyc.org/revista.oa?id=475
dc.rights	Journal of the Mexican Chemical Society
dc.rights	openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0
dc.source	Journal of the Mexican Chemical Society (México) Num.3 Vol.61
dc.subject	Química
dc.subject	Diabetes
dc.subject	Metformin
dc.subject	X-ray structures
dc.subject	ssCPMAS NMR13C
dc.subject	Melting
dc.subject	Succinate
dc.subject	mechanochemistry
dc.subject	green chemistry
dc.subject	Química	es
dc.subject	Diabetes	es
dc.subject	Metformin	es
dc.subject	X-ray structures	es
dc.subject	ssCPMAS NMR13C	es
dc.subject	Melting	es
dc.subject	Succinate	es
dc.subject	mechanochemistry	es
dc.subject	green chemistry	es
dc.subject.classification	BIOLOGÍA Y QUÍMICA
dc.title	Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties
dc.title	Synthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties	es
dc.type	Artículo
dc.type	Artículo	es
dc.road	Dorada	es
dc.ambito	Nacional	es
dc.audience	students	es
dc.audience	researchers	es
dc.type.conacyt	article
dc.identificator	2

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